Clustering of Pattern Recognition Receptors for Fungal Detection

نویسندگان

  • Makoto Inoue
  • Mari L. Shinohara
چکیده

The innate immune system is the first line of defense against invading pathogens. Innate cells recognize microbes via pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs); initiate innate immune responses; and eventually trigger adaptive immunity. Association of heterologous PRRs synergistically enhances their signal intensity. Such PRR cluster formation is essential for fungal detection in generating antifungal immunity. In this review, PRR cluster formation to detect fungi and to initiate innate immune responses is discussed.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2014